Fault Detection in Artificial Pancreas: A Model-Free Approach

Lorenzo Meneghetti1, Matteo Terzi1, Gian Antonio Susto, Simone Del Favero1, Claudio Cobelli1

  • 1University of Padova



Invited Session


10:00 - 12:00 | Mon 17 Dec | Flicker 3 | MoA08

Glucose Regulation and Biomedical Systems

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Subjects affected by Type I Diabetes (T1D) are constantly confronted with the complicated problem of administering themselves an adequate amount of insulin, so as to keep their blood-glucose concentration in a nearly physiological range. Recently, powerful technological tools have been developed to better face this challenge, in particular the so-called Artificial Pancreas (AP). Unluckily, the AP actuator, an insulin pump, is subject to faults, with potential serious consequences for subjects' safety. This calls for the development of advanced fault detection (FD) methods, leveraging the unprecedented data availability in this application. In this paper we tackle the problem of detecting insulin pump malfunctioning using a model-free approach, so that the complex sub-task of identifying a model of patient’s physiology is avoided. Moreover, we employed unsupervised methods since labeled data are hardly available in practice. The adopted data-driven Anomaly Detection (AD) methods are Local Outlier Factor and Connectivity-based Outlier Factor. The methods are applied on a feature set able to account for the physiological dynamics of T1D patients. The proposed algorithms are tested on a synthetic dataset, generated using the "UVA/Padova Type 1 Diabetic Simulator", an accurate nonlinear computer simulator of the T1D subject physiology. Both methods show precision ~75% and recall ~60%. The described approach is suitable both for embedding in medical devices, such as the AP, and implementation in cloud-based remote monitoring systems.

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