Evaluation of Fluorescent Glucose Binding Protein for Transcutaneous Glucose Monitoring at the Point of Care

Abstract

A low cost, non-invasive glucose monitoring platform can be transformative for neonatal care in low resource settings. The bacterial glucose binding protein (GBP) can be employed to measure passively-diffused glucose transcutaneously. Here, the accuracy of GBP to measure glucose was determined to be comparable to a commercial assay. Furthermore, exfoliated adult skin was explored as a potential in vivo model for neonate skin.