Constraining the Source Space Systematically Diminishes Localization Errors of Intracranial EEG based Sloreta Reconstruction

Abstract

Accurate localization of target points for direct stimulation have the potential to improve successful application of neuro-stimulation for the treatment of epilepsy. Previous studies showed, that sLORETA based on intracranial grid recording can successfully localize the maximum of a generator but exhibits a blurred activation volume. This study shows, on the basis of realistic simulations by a spatiotemporal computational model, that by restricting the source space to the gray matter ribbon more realistic estimates of the size of extended sources can be achieved.