Patient-Specific Debye Parameters for Human Blood

Abstract

This paper develops a patient-specific model for the Debye parameters of human blood based on hemoglobin content. Blood samples were collected from 176 patients visiting the University Hospital, with both permittivity measurements and standard hematological analysis performed on each blood draw. The complete blood count of each sample provided information on the hemoglobin concentration of each sample; in total there were 73 distinct hemoglobin concentrations reported. An iterative process was used to find patient-specific, based on hemoglobin content, Debye parameters. First, a two-stage genetic algorithm was used to solve for the parameters of a two-pole Debye model based on the mean-blood properties. Then, a modified two-pole Debye model incorporating hemoglobin information was developed, and those parameters were solved for using the same two-stage genetic algorithm. This paper presents the parameters for both the mean-blood¬ model and the patient-specific model. The patient-specific model has a mean-fractional error across all 73 samples of 3.41% compared to 7.64% when using the mean-blood¬ model to represent the entire population. This work demonstrates the range in the dielectric properties of human blood samples and highlights the need for incorporating patient-specific information when using the Debye parameters to model the dielectric properties of human blood.