Towards OCT-Navigated Tissue Ablation with a Picosecond Infrared Laser (PIRL) and Mass-Spectrometric Analysis

Matthias Schlüter1, Manka M. Fuh2, Stephanie Maier3, Christoph Otte1, Parnian Kiani2, Nils-owe Hansen3, R. J. Dwayne Miller3, Hartmut Schlüter2, Alexander Schlaefer1

  • 1Hamburg University of Technology
  • 2University Medical Center Hamburg-Eppendorf
  • 3Max Planck Institute for the Structure and Dynamics of Matter

Details

08:45 - 09:00 | Wed 24 Jul | M2 - Level 3 | WeA10.2

Session: Ablation Systems and Technologies

Abstract

Medical lasers are commonly used in interventions to ablate tumor tissue. Recently, the picosecond infrared laser has been introduced, which greatly decreases damaging of surrounding healthy tissue. Further, its ablation plume contains intact biomolecules which can be collected and analyzed by mass spectrometry. This allows for a specific chracterization of the tissue. For a precise treatment, however, a suitable guidance is needed. Further, spatial information is required if the tissue is to be characterized at different parts in the ablated area. Therefore, we propose a system which employs optical coherence tomography as the guiding imaging modality. We describe a prototypical system which provides automatic ablation of areas defined in the image data. For this purpose, we use a calibration with a robot which drives the laser fiber and collects the arising plume. We demonstrate our system on porcine tissue samples.