Annalisa De Angelis1, Agnese Denzi2, Caterina Merla, Franck Andre3, Tomás García-Sánchez, Lluis Mir3, Francesca Apollonio4, Micaela Liberti5
08:45 - 09:00 | Wed 24 Jul | M1 - Level 3 | WeA09.2
When investigating the biophysical effects induced by the interaction between electromagnetic fields and biological cells to mediate biomedical applications, it is crucial to estimate the electric quantities, i.e. the field intensity, at the microscopic scale to establish a connection between the external applied field and the observed biological event. Here, authors present a microdosimetric study based on a 2D realistic model of a cell and its endoplasmic reticulum. The microdosimetric analysis of the cell and endoplasmic reticulum was quantified in terms of electric field and transmembrane potentials induced by an externally applied 10-ns pulsed electric field. In addition, electroporated local membrane sites and pore densities were also considered. This study opens the way to numerically assist experimental applications of nanosecond pulsed electric fields for control and bio-manipulation of cells and subcellular organelles.