Extraction of the Fetal Pulse Curve for Transabdominal Pulse Oximetry Using Adaptive and Comb Filters

Abstract

The fetal pulse curve can be captured by placing light sources and detectors on the belly of a pregnant woman. Following the principle of reflection pulse oximetry, the light emitted into the abdomen is modulated by pulsing maternal and fetal arteries. The acquired signal is a mixture of a weak fetal and a dominating maternal photoplethysmogram (PPG). A first step towards estimation of the fetal oxygen level is the reconstruction of the purely fetal signal in time domain. As already shown in a former work, comb filters are well suited for the task, in case the fetal heart rate is known. In this work we extend the method by utilizing an adaptive noise canceller (ANC) to estimate the fetal pulse rate for comb filter design. Synthetic test signals with constant and time variable pulse rates are generated in order to achieve reproducible conditions. The ANC is fed by the mixed PPG and the maternal reference signal to reduce the dominant maternal components. The fetal pulse rate is computed by evaluating peaks in the resulting signal in time and frequency domain. The findings are used for comb filter design. It is shown that the extraction of the fetal pulse curve from the synthetic mixed PPGs by using the proposed strategy is promising. Clinical test measurements are the next step for evaluation.