CMOS Integrated Lab-on-Chip System for Personalized DNA Sequencing

Abstract

This talk will introduce emerging technologies in CMOS integrated circuits (ICs) for personalized data analysis. After brief review of recent works such as energy-efficient machine learning data-analytic chips; and smart multi-modal sensor chips, I will report recent progress on CMOS-based lab-on-chip system for personalized DNA sequencing. Starting with in-depth discussion of CMOS ion-sensitive-field-effect-transistor (ISFET) sensor chips for a scalable 2nd generation DNA sequencing, I will show the use of dual-mode (chemical + optical) ISFET sensor to improve detection accuracy, as well as the use of ISFET sensor with (time-integrated) pH-to-voltage readout at sub-threshold region for <1mV or 1pA detection resolution. Next, I will further show the present works on identifying single nucleotide bases required in the 3rd generation DNA sequencing system with CMOS-compatible integration of nanopore, nanogap and nanofilter devices.