Angle-Selective Contact Imaging of Mouse Tumor Labeled in Vivo with Trastuzumab-IR700DX

Efthymios Papageorgiou1, Bernhard Boser, Mekhail Anwar2

  • 1University of California, Berkeley
  • 2University of California, San Francisco

Details

13:30 - 15:00 | Mon 29 Oct | Ambassador A | A3L-B.1

Session: Sensors & Actuators for Animal Models

Abstract

A novel fluorescence contact imaging system is used to image mouse tumor tissue labeled in vivo using a custom fluorescence imaging agent, Trastuzumab-IR700DX. The HER2+ tumor targeted by the imaging agent is 4.5±1.1 brighter than the HER2- tumor that is not targeted. HER2+ tumor is distinguished from HER2- tumor and healthy tissue with a short integration time of 70 ms and a high SNR of 33 dB.