Wireless Optoelectronic Fiber Photometry Headstage for Deep Brain Structures Monitoring

Mehdi Noormohammadi Khiarak1, Martel Sylvain2, Yves De Koninck1, Benoit Gosselin3

  • 1Université Laval
  • 2Shenyang Institute of Automation, Chinese Academy of Sciences
  • 3Laval University

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Special Session

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08:30 - 10:00 | Mon 29 Oct | Ambassador A | A1L-B

Innovative Circuits & Techniques for Bio-Sensing, Stimulation, & Interfacing

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Abstract

This paper presents an optoelectronic neuroscience platform for monitoring neural dynamics in intact deep brain structures. A wireless optoelectronic headstage incorporating all aspects of a conventional benchtop high-performance optical fiber photometry system is presented to detect fluorescence signal fluctuations in the brain of live animal models. The headstage includes a photosensor, a fiber optic-cannula, an excitation light source, a few passive optical components, a microcontroller, a LED driver, and a wireless transceiver. All components are enclosed within a compact and light weight 3Dprinted plastic housing. The performance of the headstage was validated in-vitro with a mouse brain slice expressing GCaMP6, a genetically encoded fluorescence indicator. The proposed headstage presents a sensitivity of 50 fA over a bandwidth of 30 Hz with an excitation light power of 50 µW. The total power consumption of the headstage is approximately equal to 600 mW. The headstage prototype results in a lightweight (3.6 ≤, w/o battery) and compact device (22 × 8 × 17 mm2) which is mountable on the head of a small animal model.

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