Differentiation of C2C12 Myoblasts and Characterization of Electro-Responsive Beating Behavior of Myotubes Using Circularly Distributed Multiple Electrodes for Bio-Syncretic Robot

Chuang Zhang1, Wenxue Wang2, Ning Xi3, Yuechao Wang4, Lianqing Liu5

  • 1Shenyang Institute of Automation Chinese Academy of Sciences
  • 2Shenyang Institute of Automation, CAS
  • 3The University of Hong Kong
  • 4Shenyang Inst. of Automation
  • 5Shenyang Institute of Automation

Details

Category

Interactive Session

Sessions

10:30 - 13:00 | Tue 22 May | podC | TuA@C

Medical Robots - Design 1

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Abstract

Bio-syncretic robots, consisting of living biological materials and traditional electromechanical systems, have attracted lots of attention due to the potentialities of self-sensing, self-actuation and self-repairing with intrinsic safety and high energy conversion efficiency. However, most of current researches focus on the movement of the devices, and have ignored the study on the control of actuation unit “cells”, which is as important as motors for traditional electromechanical robots. In this work, the effects of cell culturing time, seeding concentration and functional drugs (cytochalasin and adrenalin) on contractile frequency and force strength of cardiomyocytes have been studied using scanning ion conductance microscope (SICM) and arrays of micro-pillars made of PDMS. This work will lay the foundation for the further study of quantitatively control of bio-syncretic robots actuated by cardiomyocytes and is also meaningful for the development of cytology, medicine, and clinical science.

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Summary

Diagram of Circularly Distributed Multiple Electrodes with AFM.

  • Circular distribution multiple electrodes was proposed for differentiation and control of C2C12 for bio-syncretic robots;
  • The circular distribution multiple electrodes and parallel electrodes were used to stimulation C2C12;
  • The electro-responsive beating behavior of myotubes were studied with the proposed circular electrodes.