Nonlithographic Fabrication of Inflatable and Deflatable Polydimethylsiloxane (PDMS) Micro-Channels for a Magnetically Actuated Drug Delivery System

Hyun Kim1, Pyojin Kim1, Jong Mo Seo

  • 1Seoul National University

Details

15:05 - 15:20 | Wed 12 Jul | Dunn Room | WeBT13.4

Session: Drug Delivery Routes, Release and Formulation

Abstract

An implantable drug delivery device with an inflatable/deflatable reservoir, a release rate controlling micro-channel, a syringe attachable inlet, a unidirectional channel preventing drug substances from flowing back into the inlet, and a magnetic polydimethylsiloxane (PDMS) outlet capable of on-demand drug release was designed and fabricated to realize effective drug therapy. The reservoir is refillable through the inlet, thus the device is reusable. The device does not employ photolithography patterning. Vapor coating, a precise cutting plotter, a vinyl adhesive material, and oxygen plasma treatment were employed to fabricate the device. Drug release rate was controlled by the micro-channel connected to the reservoir. Micro-channels with widths 300µm, 400µm, 500µm and depth 95µm were tested. Drug release is executed by deflecting the magnetic membrane outlet by an external electromagnetic field generating source, a permanent magnet or a planar copper coil.