Modeling Pediatric ARDS Patients

Sina Saffaran1, Anup Das, Jonathan G. Hardman, Nadir Yehya2, Declan Gerard Bates

  • 1The University of Warwick
  • 2Children's Hospital of Philadelphia



Invited Papers (Oral) [1-page]


08:00 - 09:30 | Wed 12 Jul | Webster Room | WeAT15

Modeling and Estimation of the Respiratory System for Clinical Applications


We present the adaptation of an advanced cardiorespiratory model of acute respiratory distress syndrome in adult patients to pediatric pathophysiology. We describe how model equations and parameters were revised to represent the physiological characteristics of pediatric Acute Respiratory Distress Syndrome (ARDS) patients. The adapted model was matched to data from twelve mechanically ventilated patients diagnosed with Pediatric Acute Respiratory Distress Syndrome (PARDS), and was shown to reproduce the available clinical data accurately for all patients. This new model constitutes the first detailed computational simulator specifically tailored to PARDS patients, and can be used as an investigational tool for developing and evaluating novel therapeutic strategies.

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