Multifunctional Unimolecular Micelles for Targeted Triple Negative Breast Cancer Therapy

Abstract

Unimolecular micelles, formed by single/individual multi-arm star amphiphilic block copolymers, possess outstanding in vivo stability due to their covalent nature. Thus, they are a desirable drug nanocarrier for targeted cancer therapy. We have previously demonstrated that unimolecular micelles conjugated with tumor-targeting ligands can greatly enhance the tumor accumulation and anticancer efficacy of nanoparticles in regular xenograft mouse models. Recently, we have engineered a new type of unimolecular micelle conjugated with anti-EGFR nanobody (Nb) exhibiting excellent tumor accumulation in a chemoresistant triple negative breast cancer patient derived xenograft (PDX) mouse model.