Liquid-Metal Nanomedicine for Combination Anticancer Therapy

Yue Lu1, Hu Quanyin1, Zhen Gu1

  • 1UNC at Chapel Hill / NC State

Details

Category

Invited Papers (Oral) [1-page]

Sessions

08:00 - 08:45 | Wed 12 Jul | Dunn Room | WeAT13

Pharmaceutical Engineering for Smart Drug Delivery Systems

Abstract

A liquid-gallium based nanoformulation is developed for co-delivery of a membrane-associated cytokine (TRAIL) and an intracellular-acting small-molecule drug (CDDP) to overcome drug-resistance in cancer cells. This fully biodegradable nanocarrier could intracellularly transform into therapeutic agent Ga (III) ions to facilitate to reverse drug resistance and to promote anticancer efficacy.

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