Cancer remains as one of the leading causes to human death, though medical technology has been much advanced lately. An effective treatment protocol should include the following attributes: (1) directly damaging the cancer cells and their vascular network; (2) destroying the tumor immune-suppression environment and restoring normal immune system surveillance within the body; and (3) stimulating immune response against tumor. In light of this, a new strategy for cancer therapy should synergize the external intervention with a patient's immune response. Over the past few years, a novel thermo-immune therapy was developed in our Bio-heat and Mass Transfer Laboratory. In this presentation, both the treatment system and clinical studies will be reported, including the protocol, surgical planning and the treatment outcome.