Manqing Wang1, Nan Xia1, Xiaoying Wu1, Wensheng Hou
16:00 - 17:45 | Fri 26 May | Emerald III, Rose, Narcissus & Jasmine | FrPS2T1.16
Infrared neural stimulation (INS) provides a contact free, high spatial resolution method to regulate neural activities. Due to photothermal effect, neurons which located in the beam path, could be depolarized by infrared light. How to keep the high efficiency of opto-thermal transduction in nerve tissue, and meanwhile increase the photon penetration depth in targeted tissues is the key question in current INS. Here in our study, we tried to use 980nm laser light to increase photon penetration depth in tissues, and use carbon nano-particles as photon absorber to enhance the photothermal effect of INS in sciatic nerve. The compound muscle action potentials are evoked and the radiant threshold reduces by about 2 times with carbon nano-particles. In vitro temperature measurements detect a significant temperature increment in target neurons with carbon particles during laser irradiation. These findings demonstrate that carbon nano-particles can improve the efficiency and enhance infrared neural stimulation.