Metabolic Changes after Amputation using Magnetic Resonance Spectroscopy

Zhuo Wang1, Xiaoli Guo, Yuanyuan Lyu, Yao Li, Jianbo Xiang2, Changjie Pan2, Shanbao Tong1

  • 1Shanghai Jiao Tong University
  • 2Second People's Hospital of Changzhou



Contributed Papers


11:30 - 13:30 | Fri 26 May | Emerald III, Rose, Narcissus & Jasmine | FrPS1T1

Poster I

Full Text


To study the metabolic changes following amputation, we investigated the metabolite concentrations in the secondary somatosensory cortex and thalamus from twenty-three upper limb amputees and sixteen age-matched healthy controls using proton magnetic resonance spectroscopy (MRS). The ratios of major metabolites to the creatine (Cr) peak were quantified to indicate metabolite levels. Compared with the healthy controls, the amputees showed significantly reduced NAA/Cr and Cho/Cr ratios in the secondary somatosensory cortex and thalamus contralateral to the amputation side, indicating neuronal loss and dysfunctions in these brain regions due to the loss of sensory input. Meanwhile, the stump sensation was found to be positively correlated with NAA/Cr ratio and negatively correlated with GSH/Cr ratio in the thalamus. The results suggested that both the thalamus and somatosensory cortex may undergo metabolic changes after amputation.

Additional Information

No information added


No videos found