Modeling and Simulation in Clinical Trials and Drug Development: Clinical Application of Bayesian Adaptive Dosing

Abstract

Dashboard systems for clinical decision support integrate data from multiple sources. These systems, the newest in a long line of dose calculators and other decision support tools, use Bayesian approaches to fully individualize dosing using information gathered through therapeutic drug monitoring. In one application, treating inflammatory bowel disease patients with infliximab, dashboards may reduce therapeutic failures and reduce treatment costs.