Multiscale Network Activity in Resting State FMRI

Shella D. Keilholz, Jacob Billings1, Kai wang2, Anzar Abbas1, Claudia Hafeneger3, Wen-Ju Pan1, Sadia Shakil4, Maysam Nezafati1

  • 1Emory University
  • 2Tsinghua University
  • 3Max Planck Institute
  • 4Georgia Institute of Technology

Details

Category

Invited Lectures

Theme

Biomedical Signal Processing

Sessions

08:00 - 09:30 | Wed 17 Aug | Fantasia C | WeAT3

Healthy and Altered Functional Brain Connectivity Revealed in Multimodal Data

Abstract

The brain is inherently multiscalar in both space and time. We argue that this multiscalar nature is reflected in the blood oxygenation level dependent (BOLD) fluctuations used to map functional connectivity. We present evidence that global fluctuations in activity, quasiperiodic spatiotemporal patterns, and aperiodic time-varying activity coexist within the BOLD signal. These processes can be separated using careful analysis and appear to reflect electrical activity on similar scales, suggesting that the BOLD signal fluctuations can provide novel insight into the functional architecture of the brain.

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