Characterization of the Central Sulcus in Early Childhood

Abstract

Characterization of the developing brain during early childhood is of interest for both neuroscience and medicine, and in particular, is key to understanding what goes wrong in neurodevelopmental disorders. In particular, the cortex changes rapidly in the first 3 years of life, and creating a normative atlas can provide a comparison tool to diagnose disorders at an early stage, thereby empowering early interventional therapies. Zooming in on specific sulci may provide additional targeted information, and notably, an understanding of central sulcus growth can provide important insight on the development of laterality. However, there currently do not exist any atlases of specific changes in sulci as the brain grows. In this pilot study, we explore the differences in the depth of the central sulcus between two and three year old infants using brain magnetic resonance images.